Department of Neurology
University of California, San Francisco
UCSF Sandler Neurosciences Center
675 Nelson Rising Lane, Room 514A
San Francisco, CA. 94158-0444
Mechanisms and Function of Neuromodulation
Neurons are finely tuned to extract computationally relevant features from synaptic inputs. This process is influenced heavily by neuromodulators, which can transiently retune neuronal processing by altering the properties of the membrane receptors and channels involved in synaptic transmission and cell excitability. Drugs of abuse disrupt neuromodulator signaling, ultimately producing long-lasting changes in the neuronal circuits that underlie addiction establishment, expression, and relapse.
Our lab is interested in understanding the mechanisms by which neuromodulators control excitability and synaptic integration, and how the dysfunctions in these mechanisms contribute to addiction. We employ a variety of electrophysiological, optical, and genetic techniques to probe how these neurotransmitters alter information processing in various neuronal compartments, from synaptic inputs onto dendritic spines, to transmitter release in axonal boutons. We hope that learning more about these mechanisms will lead to new targets for the treatment of addiction.